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Induction of DNA double-strand breaks by monochlorophenol isomers and ChKM in human gingival fibroblasts

✍ Scribed by M. Shehata, J. Durner, D. Thiessen, M. Shirin, S. Lottner, K. Van Landuyt, S. Furche, R. Hickel, F. X. Reichl

Book ID
118780470
Publisher
Springer-Verlag
Year
2012
Tongue
English
Weight
273 KB
Volume
86
Category
Article
ISSN
0340-5761

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In vitro exposure of normal human diploid fibroblasts (strain VH-10) to ethylene oxide (EtO) induced DNA strand breaks in the dose range of 2.5-30 mMh of EtO. Alkaline DNA unwinding (ADU), neutral filter elution (NFE), pulsed field gel electrophoresis (PFGE), and the comet assay were used to measure