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Induction of chromosomal aberrations in human lymphocytes by the antitumour alkylating agent homo-aza-steroidal ester of p-bis(2-chloroethyl)aminophenoxy acetic acid, in vitro

โœ Scribed by M.R. Tselepi; A. Zacharopoulou; N.A. Demopoulos; P. Catsoulacos


Book ID
118350084
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
375 KB
Volume
290
Category
Article
ISSN
0027-5107

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The cytogenetic effects of homo-aza-steroidal ester (ASE) on Chinese hamster ovary (CHO) cells in vitro are reported. It was found that treatment of cells with a dose as low as 0.025 pglml of ASE causes a significant number of abnormal metaphases containing mostly chromatid-type aberrations. Similar