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Chromosomal aberration and SCE induction by the cytostatic factor homo-aza-steroidal ester of p-bis(2-chloroethyl)amino phenyl acetic acid on CHO cells in culture

โœ Scribed by K. Athanasiou; N. Demopoulos


Book ID
113250471
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
103 KB
Volume
113
Category
Article
ISSN
0165-1161

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Chromosome damage and SCE induced by the
โœ Athanasiou, Kyriacos ;Demopoulos, Nicos A. ;Catsoulacos, Panayiotis ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Wiley (John Wiley & Sons) โš– 322 KB

The cytogenetic effects of homo-aza-steroidal ester (ASE) on Chinese hamster ovary (CHO) cells in vitro are reported. It was found that treatment of cells with a dose as low as 0.025 pglml of ASE causes a significant number of abnormal metaphases containing mostly chromatid-type aberrations. Similar