✦ LIBER ✦
Chromosome damage and SCE induced by the cytostatic factor homo-aza-steroidal ester of P-bis (2-chloro-ethyl) amino phenyl acetic acid in CHO cells in culture
✍ Scribed by Athanasiou, Kyriacos ;Demopoulos, Nicos A. ;Catsoulacos, Panayiotis
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1983
- Weight
- 322 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0192-2521
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✦ Synopsis
The cytogenetic effects of homo-aza-steroidal ester (ASE) on Chinese hamster ovary (CHO) cells in vitro are reported. It was found that treatment of cells with a dose as low as 0.025 pglml of ASE causes a significant number of abnormal metaphases containing mostly chromatid-type aberrations. Similarly. significant frequencies of SCE were induced with only 0.075 pg/ml of ASE.