Induction of cellular immunity by anti-idiotypic antibodies mimicking GD2 ganglioside
β Scribed by Saroj Basak; Brigitte Birebent; Enkhtsetseg Purev; Rajasekharan Somasundaram; Haruhiko Maruyama; Jan Zaloudik; Rolf Swoboda; Wolfgang Strittmatter; Weiping Li; Albrecht Luckenbach; Hong Song; Jian Li; Katrin Sproesser; Dupont Guerry; Sridar Nair; Koichi Furukawa; Dorothee Herlyn
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 354 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0340-7004
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## Abstract A small dose of the IgG~1~ fraction of antiβidiotypic antibody (ΔId 1) raised in guinea pigs against a strain A/J antibody specific for streptococcal Group A carbohydrate sensitizes A/J mice against Group A streptococci. This is opposed to the previously established suppressive function
Long-term dormancy of murine B-cell lymphomas can be experimentally induced by immunizing the host with the idiotype expressed on the tumor. Interaction of the cells with anti-idiotype antibodies is sufficient to induce and maintain the dormant state. The growth of lymphoma cells interacting with an