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Induction of B cell tumor dormancy by anti-idiotypic antibodies

✍ Scribed by Eitan Yefenof; Louis J. Picker; Richard H. Scheuermann; Ellen S. Vitetta; Nancy E. Street; Thomas F. Tucker; Jonathan W. Uhr

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 605 KB
Volume: 5
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(93)90130-k

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✦ Synopsis

Long-term dormancy of murine B-cell lymphomas can be experimentally induced by immunizing the host with the idiotype expressed on the tumor. Interaction of the cells with anti-idiotype antibodies is sufficient to induce and maintain the dormant state. The growth of lymphoma cells interacting with anti-idiotype antibodies is arrested and they undergo dramatic changes in their morphology, cell-cycle status and oncogene expression. Regrowth of a tumor after long-term dormancy results from the emergence of a tumor cell variant that no longer responds to the antibodies with growth inhibition. These data demonstrate the feasibility of reversing a malignant phenotype of cells by specific growth arrest signals and suggest new approaches for therapeutic intervention in cancer.

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