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Induction of apoptosis by quercetin: different response of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells

✍ Scribed by Fabrizia Brisdelli; Cristina Coccia; Benedetta Cinque; Maria Grazia Cifone; Argante Bozzi

Book ID: 106458091
Publisher: Springer
Year: 2006
Tongue: English
Weight: 356 KB
Volume: 296
Category: Article
ISSN: 0300-8177
DOI: 10.1007/s11010-006-9307-3

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## Abstract Fas and FasL expression upregulation was found in human leukemia K562 cells upon exposure to __Naja naja atra__ phospholipase A~2~ (PLA~2~). PLA~2~ treatment induced an increase in intracellular Ca^2+^ ([Ca^2+^]i) and ROS generation levels, leading to activation of p38 MAPK and JNK. Sup