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Differential sensitivity to resveratrol-induced apoptosis of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells

✍ Scribed by Carla Luzi; Fabrizia Brisdelli; Benedetta Cinque; Grazia Cifone; Argante Bozzi

Book ID: 113487326
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 284 KB
Volume: 68
Category: Article
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2004.07.002

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## Abstract Fas and FasL expression upregulation was found in human leukemia K562 cells upon exposure to __Naja naja atra__ phospholipase A~2~ (PLA~2~). PLA~2~ treatment induced an increase in intracellular Ca^2+^ ([Ca^2+^]i) and ROS generation levels, leading to activation of p38 MAPK and JNK. Sup