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Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDA, in chronic myeloid leukemia (K562) cells

โœ Scribed by Zchong-Zcho Wu; Ching-Ming Chien; Sheng-Huei Yang; Yi-Hsiung Lin; Xiu-Wei Hu; Yu-Jhang Lu; Ming-Jung Wu; Shinne-Ren Lin

Publisher
Springer
Year
2006
Tongue
English
Weight
257 KB
Volume
292
Category
Article
ISSN
0300-8177

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โœ Sheng-Huei Yang; Ching-Ming Chien; Chih-Ming Lu; Yeh-Long Chen; Long-Sen Chang; ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 511 KB

N'-(11H-Indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine (IQDMA), an indoloquinoline derivative, synthesized in our laboratory, has been demonstrated to be an effective anti-tumor agent in human leukemia cells. Treatment of K562 cells with IQDMA resulted in G2/M phase cell cycle arrest, pr