Induction of anti-tumor immunity by vaccination with dendritic cells pulsed with anti-CD44 IgG opsonized tumor cells
✍ Scribed by Shari Pilon-Thomas; Monique Verhaegen; Lisa Kuhn; Adam Riker; James J Mulé
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 392 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0340-7004
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Although the central nervous system (CNS) is often regarded as an immunologically privileged site, it is well established that specific CNS immunoreactivity can be generated through peripheral vaccination with CNS antigens. Dendritic cells (DC) are potent antigen presenting cells of hematopoietic or
IL-2 gene was introduced through retroviral vectors into the highly malignant and poorly immunogenic 3LL-D I22 clone. Both high and low D 122-IL-2 secretors showed elimination of tumorigenicity in syngeneic immune-competent mice; however, in nude mice only the high IL-2 secretor showed reduced tumor
The present study demonstrates that the transfection of B7-I or its variant MB7-2 genes into MHC class I+ tumor cells (B 16-BL6 or K I 735-M2 melanoma) resulted in the remarkable reduction of lung metastasis caused by i.v. injection into immunocompetent syngeneic mice. However, i.v. injection of the
## Abstract Tumor cells express tumor‐associated antigens (TAAs), which can serve as targets for the immune system. However, the majority of TAAs are overexpressed products of normal cellular genes; as such, self‐tolerance mechanisms have hindered their use for the induction of effective antitumor