Enhancement of anti-tumor immunity specific to murine glioma by vaccination with tumor cell lysate-pulsed dendritic cells engineered to produce interleukin-12

Improved efficacy of dendritic cell vacc

Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12

✍ Francesca Fallarino; Catherine Uyttenhove; Thierry Boon; Thomas F. Gajewski 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 161 KB 👁 2 views

The well-characterized P815 tumor model was used to optimize anti-tumor immunization approaches in mice. Tumor peptides derived from antigens P198 or P1A were targeted to antigen-presenting cells (APC) by ex vivo pulsing. Initial experiments with irradiated pulsed splenic dendritic cells (sDC) injec