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Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase

✍ Scribed by Robert Bockermann, David Schubert, Thomas Kamradt…

Book ID: 120707424
Publisher: BioMed Central
Year: 2005
Tongue: English
Weight: 809 KB
Volume: 7
Category: Article
ISSN: 1478-6354
DOI: 10.1186/ar1829

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## Abstract ## Objective Arthritis in the K/BxN mouse model results from pathogenic immunoglobulins that recognize glucose‐6‐phosphate isomerase (GPI), a glycolytic enzyme residing in the cytoplasm of all cells. Antibodies directed against GPI can, alone, transfer arthritis to healthy recipients.