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Clinical characteristics of anti-glucose-6-phosphate isomerase antibody-positive Japanese patients with rheumatoid arthritis

✍ Scribed by Taichi Hayashi; Isao Matsumoto; Yoshifumi Muraki; Reiko Takahashi; Yusuke Chino; Daisuke Goto; Satoshi Ito; Akito Tsutsumi; Takayuki Sumida

Book ID
106291761
Publisher
Springer
Year
2005
Tongue
English
Weight
224 KB
Volume
15
Category
Article
ISSN
1439-7595

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✍ Isao Matsumoto; David M. Lee; Raphaela Goldbach-Mansky; Takayuki Sumida; Carol A πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 300 KB πŸ‘ 2 views

## Abstract ## Objective Arthritis in the K/BxN mouse model results from pathogenic immunoglobulins that recognize glucose‐6‐phosphate isomerase (GPI), a glycolytic enzyme residing in the cytoplasm of all cells. Antibodies directed against GPI can, alone, transfer arthritis to healthy recipients.