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Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis

✍ Scribed by Floris A. van Gaalen; Rene E. M. Toes; Henrik J. Ditzel; Monica Schaller; Ferdinand C. Breedveld; Cor L. Verweij; Tom W. J. Huizinga


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
66 KB
Volume
50
Category
Article
ISSN
0004-3591

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## Abstract ## Objective Arthritis in the K/BxN mouse model results from pathogenic immunoglobulins that recognize glucose‐6‐phosphate isomerase (GPI), a glycolytic enzyme residing in the cytoplasm of all cells. Antibodies directed against GPI can, alone, transfer arthritis to healthy recipients.

Association of interleukin-6 and interle
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## Objective Recent evidence has highlighted a major genetic contribution to radiographic damage in rheumatoid arthritis (RA). The objective of this study was to determine whether genetic variants in the loci for interleukin-1 (IL-1), IL-6, IL-10, protein tyrosine phosphatase N22 (PTPN22), and sele