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Induced hepatocytes as a metabolic activation system for the mouse-lymphoma assay

โœ Scribed by Linda A. Oglesby; Karen Harrington Brock; Martha M. Moore

Book ID
119093324
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
558 KB
Volume
223
Category
Article
ISSN
0165-1218

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Large differences in induced cellular toxicity were observed in the presence or absence of a rat liver micro-soma1 metabolizing system (S-9) during drug testing in the mouse lymphoma assay. After studying the fate of three drugs in this test system, several mechanisms were demonstrated whereby S-9 r