Development of a metabolic activation system for the frog embryo teratogenesis assay: Xenopus (FETAX)
β Scribed by Douglas J. Fort; Douglas A. Dawson; John A. Bantle
- Book ID
- 112213368
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 820 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0270-3211
No coin nor oath required. For personal study only.
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## Abstract Frog Embryo Teratogenesis Assayβ__Xenopus__ (FETAX) is a 4βday, alternative developmental toxicity assay designed to preβscreen chemicals and environmental mixtures. An approach used in the scoring of FETAX results, which focuses on the determination of characteristic abnormalities indu
The potential teratogenic hazard of five compounds was evaluated using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX) and a metabolic activation system. Embryos of the South African clawed frog, Xenopus laevis, were exposed to (i) three compounds suspected to be proteratogenic in mammalian test
The Frog Embryo Teratogenesis Assay-Xenopus (FETAX) was used to assess the teratogenic potential of four solvents. Embryos of the South African clawed frog, Xenopus laevis, were exposed for 96 h to ethanol, dimethyl sulfoxide (DMSO), formamide or glycerol formal. Exposure groups were maintained usin
A reconstituted water medium was developed for use in the Frog Embryo Teratogenesis Assay--Xenopus (FETAX). FETAX solution was then tested on three compounds with known mammalian teratogenicity (ethanol, caffeine, and 5-fluorouracil) as was a non-teratogen (saccharin). The results obtained were then