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Indolizidine derivatives as potential substance P antagonists

โœ Scribed by Chuen Chan; J Derek Cocker; H Geoffrey Davies; Andrea Gore; Richard H Green


Book ID
103983232
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
183 KB
Volume
6
Category
Article
ISSN
0960-894X

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Linear amides as substance P antagonists
โœ M. Teall; T. Harrison; J.D. Moseley; A.P. Owens; S. Sadowski; M.A. Cascieri ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 166 KB

In the present study we demonstrate that an amide linking group provides an excellent template for the positioning of a benzhydryl group and a suitably functionalized aromatic ring in an orientation which allows for high affinity binding to the hNK 1 receptor.