Indoles and pyridazino[4,5-b]indoles as nonnucleoside analog inhibitors of HIV-1 reverse transcriptase
✍ Scribed by M Font; A Monge; A Cuartero; A Elorriaga; J.J. Martínez-Irujo; E Alberdi; E Santiago; I Prieto; J.J. Lasarte; P Sarobe; F Borrás
- Book ID
- 103630122
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 666 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0223-5234
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📜 SIMILAR VOLUMES
Starting from 3,6-dichloro-N-(2-chloro-5-nitrophenyl)-pyridazine-4-carboxamide (7) a series of 6,11-dialkylated pyridazino- [3,4-b][1,5]benzodiazepin-5-ones with a 3-chloro-8-nitro, 8-amino, 8-acetylamino, or 8-chloro substitution pattern was prepared via N-alkyl-3-alkylamino-6-chloro-N-(2-chloro-5-
## Abstract TIBO (Tetrahydro‐imidazo[4,5,1‐jk][1,4]‐benzodiazepin‐2‐one) and nevirapine (11‐cyclopropyl‐5,11‐dihydro‐4‐methyl‐6H‐dipyrido[3,2‐b:2′,3′‐e][1,4]diazepin‐6‐one) are models for two classes of nonnucleoside inhibitors of the HIV‐1 virus reverse transcriptase (NNRTI). This work presents th