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Indoleamine 2,3-dioxygenase in transplantation (Review Article)

✍ Scribed by WILLIAM R MULLEY; DAVID J NIKOLIC-PATERSON


Book ID
108960474
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
195 KB
Volume
13
Category
Article
ISSN
1320-5358

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## Abstract Human indoleamine 2,3‐dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L‐tryptophan (L‐Trp) and other indoleamine derivatives. Its activity follows typical Michaelis–Menten behavior only for L‐Trp concentrations up to 50 ΞΌM; a further increase in the c