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Molecules in focus: Indoleamine 2,3-dioxygenase

✍ Scribed by Nicholas J.C. King; Shane R. Thomas


Book ID
117981652
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
401 KB
Volume
39
Category
Article
ISSN
1357-2725

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## Abstract Human indoleamine 2,3‐dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L‐tryptophan (L‐Trp) and other indoleamine derivatives. Its activity follows typical Michaelis–Menten behavior only for L‐Trp concentrations up to 50 ΞΌM; a further increase in the c