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Indoleamine-2,3 dioxygenase (IDO) expression as a mechanism of immune escape by basal cell carcinoma


Book ID
116583869
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
53 KB
Volume
58
Category
Article
ISSN
1097-6787

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Immune cell proliferation is suppressed
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## Abstract Indoleamine 2,3‐dioxygenase (IDO), a tryptophan‐catabolizing enzyme, is an intracellular enzyme possessing various immunosuppressive properties. Here, we report the possible use of this enzyme to suppress proliferation of immune cells cocultured with IDO‐expressing fibroblasts of an all