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Expression of Indoleamine 2,3-Dioxygenase (IDO) by Endothelial Cells: Implications for the Control of Alloresponses

✍ Scribed by S. C. Beutelspacher; P. H. Tan; M. O. McClure; D. F. P. Larkin; R. I. Lechler; A. J. T. George


Book ID
114803904
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
424 KB
Volume
6
Category
Article
ISSN
1600-6135

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## Abstract Following CD80/86 (B7) and TLR9 ligation, small subsets of splenic dendritic cells expressing CD19 (CD19^+^ DC) acquire potent T cell regulatory functions due to induced expression of the intracellular enzyme indoleamine 2,3‐dioxygenase (IDO), which catabolizes tryptophan. In CD19^+^ DC