CXCR3 ligands promote expression of functional indoleamine 2,3-dioxygenase in basal cell carcinoma keratinocytes
β Scribed by B.K.K. Lo; R.B. Jalili; D. Zloty; A. Ghahary; B. Cowan; J.P. Dutz; N. Carr; J. Shapiro; K.J. McElwee
- Book ID
- 108671881
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 605 KB
- Volume
- 165
- Category
- Article
- ISSN
- 0007-0963
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## Abstract Indoleamine 2,3βdioxygenase (IDO), a tryptophan degrading enzyme, is a potent immunomodulatory factor. IDO expression in fibroblasts selectively induces apoptosis in immune cells but not in primary skin cells. However, the mechanism(s) of this selective effect of IDOβinduced low tryptop
## Abstract Medullary breast cancer (MBC) is a basalβlike breast carcinoma (BLBC) with a favourable outcome, whereas nonmedullary BLBC has a poor prognosis. Tumour infiltrating lymphocytes (TILs) are present in both MBC and BLBC. We hypothesized that the immunosuppressive enzyme indoleamine 2,3βdio