## Abstract ## Background Indoleamine 2,3โdioxygenase (IDO) is an enzyme involved in the catabolism of tryptophan and has been shown to prevent rejection of the fetus during pregnancy by inhibiting alloreactive T cells. ## Methods In this study we investigated dendritic cells (DCs) that are tran
Dendritic cell based antitumor vaccination: impact of functional indoleamine 2,3-dioxygenase expression
โ Scribed by Marion Wobser; Heike Voigt; Roland Houben; Andreas O. Eggert; Matthias Freiwald; Ulrike Kaemmerer; Eckhart Kaempgen; David Schrama; Juergen C. Becker
- Book ID
- 105967178
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 494 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0340-7004
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## Abstract Indoleamine 2,3โdioxygenase (IDO), a tryptophan degrading enzyme, is a potent immunomodulatory factor. IDO expression in fibroblasts selectively induces apoptosis in immune cells but not in primary skin cells. However, the mechanism(s) of this selective effect of IDOโinduced low tryptop
## Abstract Following CD80/86 (B7) and TLR9 ligation, small subsets of splenic dendritic cells expressing CD19 (CD19^+^ DC) acquire potent T cell regulatory functions due to induced expression of the intracellular enzyme indoleamine 2,3โdioxygenase (IDO), which catabolizes tryptophan. In CD19^+^ DC