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Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta

โœ Scribed by Yoshiki Kudo; C.A.R. Boyd; Isabella Spyropoulou; C.W.G. Redman; Osamu Takikawa; Takafumi Katsuki; Tetsuaki Hara; Koso Ohama; I.L. Sargent

Book ID
113752447
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
320 KB
Volume
61
Category
Article
ISSN
0165-0378

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## Abstract Human indoleamine 2,3โ€dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of Lโ€tryptophan (Lโ€Trp) and other indoleamine derivatives. Its activity follows typical Michaelisโ€“Menten behavior only for Lโ€Trp concentrations up to 50 ฮผM; a further increase in the c