Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

✍ Scribed by István Borza; Sándor Kolok; Anikó Gere; Éva Ágai-Csongor; Béla Ágai; Gábor Tárkányi; Csilla Horváth; Gizella Barta-Szalai; Éva Bozó; Csilla Kiss; Attila Bielik; József Nagy; Sándor Farkas; György Domány

• Book ID: 104364027
• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 136 KB
• Volume: 13
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(03)00708-x

✦ Synopsis

A novel series of indole-2-carboxamide derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the number and position of OH groups on the indole skeleton as well as the substitution of the piperidine ring on the biological activity of the compounds was studied.