Individualized Drug Therapy for Patients. Basic Foundations, Relevant Software and Clinical Applications

✍ Scribed by Roger W. Jelliffe and Michael Neely (Eds.)

• Publisher: Academic Press
• Year: 2016
• Tongue: English
• Leaves: 408
• Edition: 1st Edition
• Category: Library

✦ Synopsis

Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose.

The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD,renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient.

✦ Table of Contents

Content:
Front-matter,Copyright,Dedication,List of Contributors,Preface,Acknowledgments,Introduction: Don’t Just Dose—Choose a Specific Target Goal, Suited to the Patient’s Need, and Dose to Hit it Most PreciselyEntitled to full textSection I: Basic Techniques for Individualized TherapyChapter 1 - Basic Pharmacokinetics and Dynamics for Clinicians, Pages 3-18, R. Jelliffe, M. Neely
Chapter 2 - Describing Drug Behavior in Groups of Patients, Pages 19-25, R. Jelliffe
Chapter 3 - Developing Maximally Precise Dosage Regimens for Patients—Multiple Model (MM) Dosage Design, Pages 27-31, R. Jelliffe
Chapter 4 - Optimizing Laboratory Assay Methods for Individualized Therapy, Pages 33-46, R. Jelliffe
Chapter 5 - Evaluation of Renal Function, Pages 47-56, R. Jelliffe
Chapter 6 - Using the BestDose Clinical Software—Examples With Aminoglycosides, Pages 59-75, R. Jelliffe
Chapter 7 - Monitoring the Patient: Four Different Bayesian Methods to Make Individual Patient Drug Models, Pages 77-90, R. Jelliffe, A. Schumitzky, D. Bayard, M. Neely
Chapter 8 - Monitoring Each Patient Optimally: When to Obtain the Best Samples for Therapeutic Drug Monitoring, Pages 91-102, R. Jelliffe, D. Bayard, M. Neely
Chapter 9 - Optimizing Individualized Drug Therapy in the ICU, Pages 103-114, R. Jelliffe
Chapter 10 - Quantitative Modeling of Diffusion Into Endocardial Vegetations, the Postantibiotic Effect, and Bacterial Growth and Kill, Pages 115-134, R. Jelliffe
Chapter 11 - Individualizing Digoxin Therapy, Pages 135-154, R. Jelliffe
Chapter 12 - Optimizing Single-Drug Antibacterial and Antifungal Therapy, Pages 157-179, M. Neely, R. Jelliffe
Chapter 13 - Combination Chemotherapy With Anti-Infective Agents, Pages 181-206, G.L. Drusano
Chapter 14 - Controlling Antiretroviral Therapy in Children and Adolescents with HIV Infection, Pages 207-238, M. Neely, N.Y. Rakhmanina
Chapter 15 - Individualizing Tuberculosis Therapy, Pages 239-254, S. Goutelle, P. Maire
Chapter 16 - Individualizing Transplant Therapy, Pages 255-279, P. Marquet, A. Åsberg
Chapter 17 - Individualizing Dosage Regimens of Antineoplastic Agents, Pages 281-306, A. Aldaz, P. Schaiquevich
Chapter 18 - Controlling Busulfan Therapy in Children, Pages 307-326, M. Neely, M. Philippe, N. Bleyzac, S. Goutelle
Chapter 19 - Individualizing Antiepileptic Therapy for Patients, Pages 327-371, I. Bondareva
Chapter 20 - Individualizing Drug Therapy in the Elderly, Pages 373-382, P. Maire, L. Bourguignon, S. Goutelle, M. Ducher, R. Jelliffe
Chapter 21 - The Present and Future State of Individualized Therapy, Pages 383-392, R. Jelliffe, M. Neely
Index, Pages 393-399

✦ Subjects

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