Intrabodies: Basic Research and Clinical Gene Therapy Applications

✍ Scribed by Wayne A. Marasco (auth.), Wayne A. Marasco M.D., Ph.D. (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1998
• Tongue: English
• Leaves: 221
• Edition: 1
• Category: Library

✦ Table of Contents

Front Matter....Pages i-xiv
Designing Intrabodies: Structural Features and the Use of Intracellular Trafficking Signals....Pages 1-22
Phage Libraries for Generation of Single Chain Fv Antibodies for Intracellular Immunization....Pages 23-46
Phenotypic Knockout of the Human Interleukin-2 Receptor α Chain on Primary and HTLV-I Transformed T Cells....Pages 47-60
Intracellular Antibodies as Tools to Study ErbB Receptor Tyrosine Kinases....Pages 61-74
Neuroantibodies: The Use of Recombinant Antibody Expression in the Central Nervous System....Pages 75-96
Intracellular Antibody-Mediated Knockout of the ErbB-2 Oncoprotein as a Cancer Gene Therapy Approach....Pages 97-128
Intracellular Targeting of Oncogenes: A Novel Approach for Cancer Therapy....Pages 129-146
Intrabodies Against the HIV-1 Regulatory Proteins: Tat and Rev as Targets for Gene Therapy....Pages 147-161
Gene Therapy for HIV-1 Using Intracellular Antibodies Against HIV-1 Gag Proteins....Pages 163-181
Single Chain Variable Fragment-Based Strategies for Anti-HIV-1 Gene Therapy: Targeting the Viral Preintegration Complex and Combination Molecular Approaches....Pages 183-208
Back Matter....Pages 209-211

✦ Subjects

Molecular Medicine; Human Genetics; Cell Biology; Cancer Research