Internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation, and what impact these advances might optimally have on medicine and sci
Xenotransplantation: Basic Research and Clinical Applications
โ Scribed by Jeffrey L. Platt MD,PhD (auth.), Jeffrey L. Platt MD (eds.)
- Publisher
- Humana Press
- Year
- 2002
- Tongue
- English
- Leaves
- 269
- Edition
- 1
- Category
- Library
No coin nor oath required. For personal study only.
โฆ Synopsis
Xenotransplantation might well provide a revolutionary way of augmenting the function of diseased tissues or replacing organs. This possibility has been advanced by newly acquired understanding of the biological and immunological obstacles to conducting transplantation between species. In Xenotransplantation: Basic Research and Clinical Applications, internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft, and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.
Comprehensive and authoritative, Xenotransplantation: Basic Research and Clinical Applications provides basic and clinical investigators, as well as transplant surgeons, with today's most thorough and up-to-date compendium of vital information on all the scientific and technological aspects of xenotransplantation.
โฆ Table of Contents
Front Matter....Pages i-x
Molecular and Cellular Hurdles to Xenotransplantation....Pages 1-43
Pathological Responses to Xenotransplantation....Pages 45-55
Natural Xenoreactive Antibodies....Pages 57-71
Specificity of Xenoreactive Natural Antibodies....Pages 73-85
Biophysical Properties of Xenoreactive Natural Antibodies....Pages 87-101
The Origin of Xenoreactive Natural Antibodies....Pages 103-118
Synthesis of Carbohydrate Antigens Recognized by Xenoreactive Antibodies....Pages 119-137
The Complement Barrier to Xenotransplantation....Pages 139-171
Defects and Amplification of Costimulation Across the Species....Pages 173-197
Antibody-Dependent Effects on Cellular Immunity....Pages 199-214
Disordered Regulation of Coagulation and Platelet Activation in Xenotransplantation....Pages 215-246
Current Applications of Cellular Xenografts....Pages 247-263
Back Matter....Pages 265-270
โฆ Subjects
Transplant Surgery; Theory of Medicine/Bioethics; Immunology
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