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Increasing Rates of Reaction: Microwave-Assisted Organic Synthesis for Combinatorial Chemistry
β Scribed by Lew, Amy; Krutzik, Peter O.; Hart, Matthew E.; Chamberlin, A. Richard
- Book ID
- 118264330
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 258 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1520-4766
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A new highly efficient MICROCOS technology (Microwave-assisted Combinatorial Synthesis) for generating combinatorial libraries is described. The technology is applied to the high throughput, automated, one-step, parallel synthesis of diverse substituted pyridines using the Hantzsch synthesis. The ad
A series of functionalized resins were synthesized from Merrifield resin by virtue of microwave irradiation. A significant reduction in reaction time was achieved. This method provides a rapid transformation of functionalized resin in solid-phase synthesis.