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Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease

โœ Scribed by J. Wang; S. Xiong; C. Xie; W. R. Markesbery; M. A. Lovell


Book ID
111178826
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
239 KB
Volume
93
Category
Article
ISSN
0022-3042

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โœ Mark A. Smith; Keisuke Hirai; Akihiko Nunomura; George Perry ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 125 KB ๐Ÿ‘ 3 views

The most striking feature of Alzheimer's disease (AD) is the number of abnormalities affecting essentially every aspect of brain homeostasis. Recent work suggests that increased oxidative stress that damages lipids, proteins, and nucleic acids and results in the accumulation of redox-active metals m