Oxidative damage in the olfactory system in Alzheimer's disease
β Scribed by George Perry; RudyJ. Castellani; MarkA. Smith; PeggyL.R. Harris; Zvezdana Kubat; Kasra Ghanbari; PaulK. Jones; Giovanni Cordone; Massimo Tabaton; Benjamin Wolozin; Hossein Ghanbari
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 287 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0001-6322
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## Abstract Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with lateβstage AD (LAD
The most striking feature of Alzheimer's disease (AD) is the number of abnormalities affecting essentially every aspect of brain homeostasis. Recent work suggests that increased oxidative stress that damages lipids, proteins, and nucleic acids and results in the accumulation of redox-active metals m