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Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

✍ Scribed by Jianquan Wang; William R. Markesbery; Mark A. Lovell

Book ID
111179350
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
107 KB
Volume
96
Category
Article
ISSN
0022-3042

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✍ Mark A. Lovell; William R. Markesbery 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB 👁 1 views

## Abstract Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late‐stage AD (LAD