Increased levels of spontaneous and mutagen-induced chromosome aberrations in skin fibroblasts from patients with adenomatosis of the colon and rectum
✍ Scribed by Sverre Heim; Sidsel Greff Johansen; Anne-Marie Kolnig; Bodil Strömbeck
- Book ID
- 119103018
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 545 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Chemical transformation of cultured human skin fibroblasts (PF) derived from individuals with hereditary adenomatosis of the colon and rectum is reported. Cells treated only with various levels of N‐methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG) underwent morphological alteration. The morpho
## Abstract A heritable propensity to develop malignant lesions is found in individuals with familial adenomatosis of the colon and rectum (ACR) and the Gardner's syndrome variant, an autosomal dominant trait. In the present study, the growth characteristics of cultured skin fibroblasts (SF) derive