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Increased iron content in the putamen of patients with striatonigral degeneration

✍ Scribed by S. Kato; S. Meshitsuka; E. Ohama; J. Tanaka; J. F. Llena; A. Hirano

Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
674 KB
Volume
84
Category
Article
ISSN
0001-6322

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✦ Synopsis

We measured the total content of iron, copper, zinc and manganese in the putamen of four patients with striatonigral degeneration (SND) and age- and gender-matched normal controls. The iron content in the SND patients was five times greater than in the controls. Electron microscopic histochemistry revealed the iron reaction products in the pigments showing a triphasic pattern of coarse, electron-dense globules, fine granular and fibrillary materials, and lamellated structures. These findings suggest that increased iron deposition may be related to pigment formation in the putamen of SND.

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