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Cell type-specific neuronal loss in the putamen of patients with multiple system atrophy

✍ Scribed by Kenta Sato; Ryuji Kaji; Sadayuki Matsumoto; Satoshi Goto

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
242 KB
Volume
22
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Using antibodies to calcineurin (CaN) and choline acetyltransferase (ChAT), we performed topographical and cellular immunohistochemical analysis on the posterior putamen of autopsied patients with multiple system atrophy with predominant parkinsonism (MSA‐P). We document that in these patients, medium spiny neurons positive for CaN were severely depleted in the dorsolateral portion of the posterior putamen where ChAT‐positive neurons are normally distributed. Our findings indicate that in patients with MSA‐P, striatal neurons manifest a cell type‐specific vulnerability to neurodegeneration. Β© 2007 Movement Disorder Society

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