## Abstract ## Purpose To estimate the levels of basal ganglia iron levels in Parkinson's disease (PD) using the PRIME MR sequence at 3.0 Tesla, in relation to patients' motor symptom severity. ## Materials and Methods Seventy patients with PD and 10 healthy controls underwent assessment of move
MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease
β Scribed by P. Kosta; M. I. Argyropoulou; S. Markoula; S. Konitsiotis
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 301 KB
- Volume
- 253
- Category
- Article
- ISSN
- 0340-5354
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## Abstract The possibility of using magnetic resonance (MR) to evaluate the severity of the pathological changes of Parkinson's disease (PD) is suggested by the known accumulation of iron in the basal ganglia in PD and the reduced signal evident from this area with conventional reduced signal evid
Postmortem demonstration of increased iron in the substantia nigra (SN) is a well-appreciated finding in Parkinson's disease (PD). Iron facilitates generation of free radicals, which are thought to play a role in dopamine neuronal loss. To date, however, magnetic resonance imaging (MRI) has failed t