𝔖 Bobbio Scriptorium
✦   LIBER   ✦

INCREASED FREQUENCY OF HLA–DR5 IN SCLERODERMA

✍ Scribed by Dafna D. Gladman; Edward C. Keystone; Murray Baron; Peter Lee; Donna Cane; Helen Mervert

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
227 KB
Volume
24
Category
Article
ISSN
0004-3591

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✦ Synopsis

Progressive systemic sclerosis (scleroderma) is a connective tissue disease of unknown etiology (1). The demonstration of a mononuclear cell infiltrate in the early lesions of scleroderma and the frequent occurrence of serologic abnormalities suggest an immunologic pathogenesis for this disease (1). Furthermore, the disease is often seen in association with other collagen diseases such as rheumatoid arthritis, polymyositis, and systemic lupus erythematosus in which immunologic injury is thought to play a role.

The HLA-D locus of the major histocompatibility complex in humans is thought to code for immune response genes (2). Associations between HLA-D locus antigens and both rheumatoid arthritis and systemic lupus erythematosus have recently been demonstrated (3-6). We have therefore assessed B cell alloantigens in a group of patients with scleroderma. The results dem-

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