Increased α2-adrenergic constriction of isolated arterioles in diffuse scleroderma

Efficacy and tolerability of a selective

Efficacy and tolerability of a selective α2C-adrenergic receptor blocker in recovery from cold-induced vasospasm in scleroderma patients: A single-center, double-blind, placebo-controlled, randomized crossover study

✍ Robert A. Wise; Fredrick M. Wigley; Barbara White; Gwen Leatherman; Jianhua Zhon 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 98 KB

## Abstract ## Objective OPC‐28326 is a selective α‐adrenergic antagonist with preferential binding to the α~2C~‐adrenergic receptor (α~2C~‐AR) subtype. This study observed the effect of OPC‐28326 on skin temperature and digital blood flow following an acute cold challenge in patients with Raynaud