Increased expression of hepatitis B virus surface antigen gene inEscherichia coliby IS1 insertion
β Scribed by Kazuo Nakahama; Yasuaki Itoh; Yukio Fujisawa; Masakazu Kikuchi
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 425 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1432-0614
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## Abstract We previously showed that hepatitis B surface antigen (HBsAg)βproducing transgenic mice were more sensitive to hepatocarcinogens than their normal littermates were. We have now investigated the regulation of hepatitis B virus (HBV) gene expression in carcinogenβinduced liver tumors of H
We have constructed a recombinant SV40-based vector carrying the S gene coding for the hepatitis B virus surface antigen (HBsAg). This vector replicates as an episome in monkey COS7 cells, producing high levels of hepatitis B virus surface antigen (HBsAg), which is liberated in the cell medium, prob