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Increased expression of hepatic DNA methyltransferase in smokers

โœ Scribed by G.J. Hammons; Y. Yan; N.G. Lopatina; B. Jin; C. Wise; E.B. Blann; L.A. Poirier; F.F. Kadlubar; B.D. Lyn-Cook

Book ID
110252866
Publisher
Springer
Year
1999
Tongue
English
Weight
87 KB
Volume
15
Category
Article
ISSN
0742-2091

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In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis.