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Expression of DNA methyltransferases in multistep hepatocarcinogenesis

โœ Scribed by Mi Sun Choi; Yhong-Hee Shim; Jung Yong Hwa; Seung Kyu Lee; Jae Y. Ro; Jung-Sun Kim; Eunsil Yu

Book ID
117818766
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
246 KB
Volume
34
Category
Article
ISSN
1532-8392

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In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis.