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Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas

โœ Scribed by Dun-Fa Peng; Yae Kanai; Morio Sawada; Saori Ushijima; Nobuyoshi Hiraoka; Tomoo Kosuge; Setsuo Hirohashi

Book ID
108583512
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
241 KB
Volume
96
Category
Article
ISSN
1347-9032

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Increased protein expression of DNA meth
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas
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## Abstract Alteration of DNA methylation is one of the most consistent epigenetic changes in human cancers. DNA methyltransferase (DNMT) 1 is a major enzyme involved in establishing genomic methylation patterns. Most of the studies concerning DNMT1 expression in human cancers have been performed o