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Increased DNA Methyltransferase 1 Protein Expression in Human Transitional Cell Carcinoma of the Bladder

✍ Scribed by NAKAGAWA, TOHRU; KANAI, YAE; SAITO, YOSHIMASA; KITAMURA, TADAICHI; KAKIZOE, TADAO; HIROHASHI, SETSUO

Book ID
121938078
Publisher
Lippincott Williams and Wilkins
Year
2003
Tongue
English
Weight
367 KB
Volume
170
Category
Article
ISSN
0022-5347

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πŸ“œ SIMILAR VOLUMES

Decrease of DNA methyltransferase 1 expr
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma
✍ Fumihiro Kimura; Hans-Helge Seifert; Andrea R. Florl; Simon Santourlidis; Christ πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 368 KB

In many common cancers such as transitional cell carcinoma (TCC), specific genes are hypermethylated, whereas overall DNA methylation is diminished. Genome-wide DNA hypomethylation mostly affects repetitive sequences such as LINE-1 retrotransposons. Methylation of these sequences depends on adequate