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901 DNA methyltransferase (DNMT) 1 protein expression is significantly increased in human hepatocellular carcinomas with malignant potential and may be a biological predictor of prognosis in hepatocellular carcinoma patients

✍ Scribed by Yoshimasa Saito; Yae Kanai; Tohru Nakagawa; Michiie Sakamoto; Hidetsuga Saito; Hiromasa Ishii; Setsuo Hirohashi

Book ID: 119530806
Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 100 KB
Volume: 38
Category: Article
ISSN: 0270-9139
DOI: 10.1016/s0270-9139(03)80942-4

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Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas

✍ Yoshimasa Saito; Yae Kanai; Tohru Nakagawa; Michiie Sakamoto; Hidetsugu Saito; H 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 240 KB

## Abstract Alteration of DNA methylation is one of the most consistent epigenetic changes in human cancers. DNA methyltransferase (DNMT) 1 is a major enzyme involved in establishing genomic methylation patterns. Most of the studies concerning DNMT1 expression in human cancers have been performed o