Increase of dihydrofolate reductase in peripheral blood lymphocytes of rheumatoid arthritis patients treated with low-dose oral methotrexate
β Scribed by Sjoerd Rodenhuis; Joel M. Kremer; Joseph R. Bertino
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 652 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0004-3591
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π SIMILAR VOLUMES
Objective. To evaluate the influence of food on the bioavailability of an oral dose of methotrexate in patients with rheumatoid arthritis. Methods. Methotrexate (15 mg) was given intravenously and orally, with or without a meal, to 10 patients. Blood samples were drawn at specific intervals to eval
Polymorphonuclear leukocytes (PM Ns) isolated from peripheral blood and synovial fluid o f patients with rheumatoid arthritis and from peripheral blood o f volunteers were stimulated with 12-phorbol-13-myristate acetate (PMA). No significant differences in luminol-amplified chemiluminescence were fo