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Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats

✍ Scribed by Juan Andrés Abin-Carriquiry; Jessika Urbanavicius; Cecilia Scorza; Marcos Rebolledo-Fuentes; Susan Wonnacott; Bruce K. Cassels; Federico Dajas


Book ID
113588672
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
598 KB
Volume
634
Category
Article
ISSN
0014-2999

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## Abstract Excessive glutamate transmission in the basal ganglia is a major factor in the neural mechanisms underlying parkinsonian akinesia. Activation of K opioid receptors causes a presynaptic reduction in glutamate release. K opioid receptors are concentrated in those regions of the basal gang