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Incorporation of amide linked thymidine dimers into oligodeoxynucleotides

✍ Scribed by Garimella Viswanadham; Gorm V. Petersen; Jesper Wengel


Book ID
103983394
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
227 KB
Volume
6
Category
Article
ISSN
0960-894X

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An efficient synthesis of urea, N-methyl urea and catbamate linked thymidine dimers has been accomplished. Incorporation of the dimers one or three times into a DNA oligonucleotide. via solid-phase synthesis, was performed. Thermal denatmation studies indicated that the urea-linked 12-mers selective