𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Incorporation of 5-azacytidine into liver ribonucleic acids of leukemic mice sensitive and resistant to 5-azacytidine

✍ Scribed by A. Čihák; J. Veselý; F. Šorm

Book ID
115741820
Publisher
Elsevier Science
Year
1965
Weight
179 KB
Volume
108
Category
Article
ISSN
0005-2787

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Biochemical changes associated with the
Biochemical changes associated with the development of resistance to 5-azacytidine in AKR leukemic mice
✍ J. Veselý; J. Seifert; A. Čihák; F. Šorm 📂 Article 📅 1966 🏛 John Wiley and Sons 🌐 French ⚖ 629 KB

Resistance to 5-azacytidine, a potent inhibitor of the growth of mouse lymphoid leukemia cells in vivo, was achieved in an inbred strain of A K R mice in the third transplant period. The incorporation of orotic acid into the livers of such resistant mice was more than six times lower than in animals

Biochemical mechanisms of drug resistanc
Biochemical mechanisms of drug resistance — XII. Uridine kinases from mouse leukemic cells sensitive and resistant to 5-azacytidine
✍ J. Veselý; M. Dvořák; A. Čihák; F. Šorm 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 639 KB

## Abstract Partially purified uridine kinases from 5‐azacytidine‐sensitive and ‐resistant leukemic cells of AKR mice were separated on a Sephadex G‐200 column. The elution profile of both enzymes was similar although specific activity of uridine kinase from 5‐azacytidine‐resistant cells was more t

Biochemical mechanisms of drug resistanc
Biochemical mechanisms of drug resistance IV. Development of resistance to 5-azacytidine and simultaneous depression of pyrimidine metabolism in leukemic mice
✍ J. Veselý; A. Čihák; F. Šorm 📂 Article 📅 1967 🏛 John Wiley and Sons 🌐 French ⚖ 547 KB

The development of resistance of leukemic AKR mice to 5-azacytidine administered in small doses was investigated. The activity of uridine kinase decreased simultaneously with the development of resistance. The gradual shortening of the survival time of treated animals and the depression of enzyme ac

Activity of uridine kinase in different
Activity of uridine kinase in different lines of AKR leukemic mice and its relation to chemotherapy with 5-azacytidine
✍ J. Veselý 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 472 KB

## Abstract The sensitivity of different wild‐type and 5‐azacytidine‐resistant lines of AKR leukemic mice to 5‐azacytidine varies in relation to the activity of uridine kinase isolated from corresponding leukemic livers. The enhancement of liver uridine kinase activity observed in leukemic mice fol