✍ Scribed by J. Veselý; A. Čihák; F. Šorm
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The development of resistance of leukemic AKR mice to 5-azacytidine administered in small doses was investigated. The activity of uridine kinase decreased simultaneously with the development of resistance. The gradual shortening of the survival time of treated animals and the depression of enzyme ac
## Abstract Partially purified uridine kinases from 5‐azacytidine‐sensitive and ‐resistant leukemic cells of AKR mice were separated on a Sephadex G‐200 column. The elution profile of both enzymes was similar although specific activity of uridine kinase from 5‐azacytidine‐resistant cells was more t
Resistance to 5-azacytidine, a potent inhibitor of the growth of mouse lymphoid leukemia cells in vivo, was achieved in an inbred strain of A K R mice in the third transplant period. The incorporation of orotic acid into the livers of such resistant mice was more than six times lower than in animals